​Current Research Projects


The Nicotine Science Center is currently involved in Master, PhD and Cross-disciplinary international collaboration research projects together with Danish and European universities. Below is a brief description of individual projects:

Project 1:

Aim of the project: The aim of the project is to identify the basic permeability barriers controlling the absorption of nicotine through the oral mucosa. Furthermore we want to identify methods to improve permeability of nicotine through the oral mucosa. 

Partners: University of Copenhagen (Denmark)

Project Type: PhD Study Project (2014 – 2016)

Funding: 2/3 of costs are funded by the NSC and 1/3 by the University of Copenhagen.

NSC Contribution: The NSC provides supervision and additional funding if needed.

Expected benefits for NSC: Insight into factors impacting the permeation of nicotine through the oral mucosa for possible use in improved NRT drug products.  

NSC Contact Person: Birgitte Hyrup Andersen, Fertin Pharma A/S.

Project 2:

Aim of the project: The aim of the project is to identify the basic mechanisms in the mouth cavity leading to pain, sensitization and vasomotor responses initiated by intake of nicotine from NRT products.

Partners: Aalborg University (Denmark)

Project Type: Bachelor Study Project (2013 – 2014)

Funding: Funded by Aalborg University.

NSC Contribution: The NSC participates with  preparation of nicotine containing products, and financial support to execution of pre-clinical studies related to the project.   

Expected benefits for NSC: NSC gets insight into factors initiating pain, sensitization and vasomotor responses in the buccal cavity during intake of nicotine from NRT products for possible use in improved NRT drug products.  

NSC Contact Person: Kent Albin Nielsen, Fertin Pharma A/S.

Project 3

Aim of the project: The aim of the project is the development, functionalization and characterization of functional nano-microstructure assemblies using food grade biopolymers (polysaccharies and proteins), as well as lipids. These nano-microstructures can be used for protection, targeting, and delivery of bioactive components, among others.

Partners: the Technical University of Denmark (Denmark), the University of Copenhagen (Denmark),  Lund University (Sweden) and the University of Münster (Germany). The project name is FENAMI (DSF10-093456).

Project Type: Cross-disciplinary international collaboration project (2011 – 2015)

Funding: The Danish Council for Strategic Research has granted financial support.

NSC contribution: The NSC participates with preparation and testing of pre-blends with nicotine.

Expected benefits for NSC: Insight into application of nano-microstructures for possible use as carriers of nicotine in NRT drug formulations.    

NSC Contact: Kent Albin Nielsen, Fertin Pharma A/S.

Project 4

Aim of the project: ​​To investigate the binding mechanisms/kinetics between Nicotine and selected ion-exchange resins in order to reveal the eventual impact of formulation designs on the thermodynamic mechanisms governing the respective equilibrium constant. Also, loading- and release-profiles will be investigated.​

Partners: SDU Odense (FKF) (Denmark)

Project Type: Ph.D. Study Project (2015-2016)  

Funding: Approximately 1/4 of costs are funded by the NSC and 3/4 from other funds.

NSC contribution: The NSC provides supervision.

Expected benefits for NSC: Insight into factors impacting the loading and release of nicotine from selected ion-exchange resins.   

NSC Contact: Kent Albin Nielsen, Fertin Pharma A/S.

Project 5

Aim of the project: Investigating the possibility of improving iron absorption using chewing gum.​

Partners: Technical University of Denmark

Project Type: Ph.D. Study Project (2012-2015)

Funding: Danish Strategic Research Council (via Project FENAMI, DSF-10-93456)

NSC contribution: Chewing gum for the study were manufactured by Fertin Pharma.

NSC Contact: Kent Albin Nielsen, Fertin Pharma A/S.